33  The Miller Experiment
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In 1953, the biologist and chemist Stanley L. Miller constructed a test apparatus with which he wanted to simulate the development of amino acids under primordial soup conditions. He was successful in synthesizing various simple amino acids by means of spark discharge in a gas mixture over a number of days. However, his experiment has become insignificant in present molecular biology for a number of reasons: The water in Miller’s primordial soup prevents the formation of chain molecules. Toxic substances also developed in his primordial soup. The experiment was accomplished under the exclusion of oxygen and does otherwise not coincide with today’s knowledge regarding the primordial atmosphere of the earth.


For some time, Stanley L. Miller’s experiment was celebrated as a resounding success for the evolution theory. Even today, many school books still contend that life began with lightning acting on a particular primordial atmosphere. At that time, the first basic building blocks of life, the amino acids, evolved supposedly. The Miller Experiment allegedly provides proof that such a scenario in natural science (1) is reproducible.


Miller-Urey Experiment  










Setup of the Miller-Urey experiment:


40 years after which he had become famous for his primordial soup experiment Miller distanced himself from the idea that life could develop in a primordial soup.



However, the primordial soup experiments performed by Stanley Miller and others have become uninteresting, because only a fraction of the necessary basic building blocks for life develop under the described primordial soup conditions (2).

The biochemist Klaus Dose came to a sobering conclusion still valid today, following the 8th international conference on the origin of life. He had to recognize that “a major portion of the reaction products from simulation experiments were no closer to life than the contents of coal tar” (3).

In spite of – or perhaps due to – numerous experiments on the origin of life, the insight is increasing that natural chemical processes are not able to initiate life.


Concentration and practical combination of amino acids:

Even if amino acids were formed in a primordial soup, it would be necessary for them to concentrate in a further step and combine spontaneously to form practical molecular chains capable of carrying information. At least 500,000 base-pairs are required to produce even the DNA of the simplest bacteria. Simultaneously it is necessary to form cell tissue, cell walls and various mechanisms so that the cell is viable from the very beginning.


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References:

(1) Stanley L. Miller, A Production of Amino Acids Under Possible Primitive Earth Conditions, Science 117, 15 May, 1953, P. 528–529.
(2) Paul Lüth, Der Mensch ist kein Zufall, DVA, Stuttgart, 1981, P. 46–64.
(3) Bruno Vollmert, Das Molekül und das Leben, Rowohlt, 1985, P. 39–45.
 
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